Reproductive ToxicologyVolume 36, April 2013, Pages 18-23

The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity(Article)

  • aClinical Center for Urological Disease Diagnosis, Private Clinic Specialized in Urological and Andrological Genetics, Tehran, Iran
  • bUrology Research Center, Guilan University of Medical Sciences, Rasht, Iran
  • cDepartment of Urology, Tabriz University of Medical Sciences, Tabriz, Iran
  • dDepartment of Psychiatry, Faculty of Medicine, Shahed University, Tehran, Iran
  • eDepartment of Health and Community Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • fResearch Center, Department of Biotechnology, Medical Faculty, Aja University of Medical Sciences, Tehran, Iran
  • gResearch Center, Department of Clinical Epidemiology, Medical Faculty, Aja University of Medical Sciences, Tehran, Iran


We evaluated the effects of opiate consumption on semen quality, sperm function, seminal plasma antioxidant capacity, and sperm DNA integrity. A total of 142 opiate addict men (group 1) were enrolled in the study and 146 healthy age matched male volunteers (group 2) served as controls. Two semen analyses were performed in all participants. Sperm chromatin structure assay (SCSA) was used to identify sperm DNA integrity. The mean ± SD sperm concentration in opiate users and in control subjects was 22.2 ± 4.4 and 66.3 ± 8.3 million per ml, respectively (P=0.002). A significant increase in the amount of fragmented DNA was found in opiate consumers compared with that in controls (36.4 ± 3.8% vs. 27.1 ± 2.4%, P=. 0.004). Significantly decreased levels of catalase-like and superoxide dismutase-like (SOD) activity were observed in group 1 compared with group 2. Opiate consumption has significant adverse effects on semen quality. In cases of unexplained infertility in men, opium consumption should be considered as a possible factor. © 2012 Elsevier Inc.

Author keywords

  • Acrosome reaction
  • Addiction
  • DNA fragmentation
  • Dugs
  • Male infertility
  • Substance abuse

Indexed keywords

EMTREE drug terms:catalasefollitropinliothyronineluteinizing hormoneopiatesex hormone binding globulinsuperoxide dismutasetestosteronethyrotropin
EMTREE medical terms:adultarticlechromatin structureconcentration (parameters)controlled studyDNA determinationDNA fragmentationejaculationenzyme activityfollitropin blood levelhumanliothyronine blood levelluteinizing hormone blood levelmajor clinical studymalemale genital tract parametersmale infertilityoligospermiaopiate addictionoxidative stresssemen analysissperm qualityspermatozoon motilitytesticular volumetestosterone blood levelthyrotropin blood level
MeSH:Acrosome ReactionAdultAnalgesics, OpioidCase-Control StudiesChromatinDiagnostic and Statistical Manual of Mental DisordersDNA DamageGonadal Steroid HormonesGonadotropins, PituitaryHallucinogensHumansInfertility, MaleMaleMiddle AgedOpioid-Related DisordersOxidoreductasesSemenSpermatozoaSubstance Abuse DetectionYoung Adult

Chemicals and CAS Registry Numbers:

catalase, 9001-05-2; follitropin, 9002-68-0; liothyronine, 6138-47-2, 6893-02-3; luteinizing hormone, 39341-83-8, 9002-67-9; opiate, 53663-61-9, 8002-76-4, 8008-60-4; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; testosterone, 58-22-0; thyrotropin, 9002-71-5;

Analgesics, Opioid; Chromatin; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Hallucinogens; Oxidoreductases, 1.-

  • ISSN: 08906238
  • Source Type: Journal
  • Original language: English
  • DOI: 10.1016/j.reprotox.2012.11.010
  • PubMed ID: 23207164
  • Document Type: Article

  Safarinejad, M.R.; P.O. Box 19395-1849, Iran; email:[email protected]
© Copyright 2013 Elsevier B.V., All rights reserved. © MEDLINE® is the source for the MeSH terms of this document.


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