We evaluated the effects of opiate consumption on semen quality, sperm function, seminal plasma antioxidant capacity, and sperm DNA integrity. A total of 142 opiate addict men (group 1) were enrolled in the study and 146 healthy age matched male volunteers (group 2) served as controls. Two semen analyses were performed in all participants. Sperm chromatin structure assay (SCSA) was used to identify sperm DNA integrity. The mean ± SD sperm concentration in opiate users and in control subjects was 22.2 ± 4.4 and 66.3 ± 8.3 million per ml, respectively (P=0.002). A significant increase in the amount of fragmented DNA was found in opiate consumers compared with that in controls (36.4 ± 3.8% vs. 27.1 ± 2.4%, P=. 0.004). Significantly decreased levels of catalase-like and superoxide dismutase-like (SOD) activity were observed in group 1 compared with group 2. Opiate consumption has significant adverse effects on semen quality. In cases of unexplained infertility in men, opium consumption should be considered as a possible factor. © 2012 Elsevier Inc.
|EMTREE drug terms:||catalasefollitropinliothyronineluteinizing hormoneopiatesex hormone binding globulinsuperoxide dismutasetestosteronethyrotropin|
|EMTREE medical terms:||adultarticlechromatin structureconcentration (parameters)controlled studyDNA determinationDNA fragmentationejaculationenzyme activityfollitropin blood levelhumanliothyronine blood levelluteinizing hormone blood levelmajor clinical studymalemale genital tract parametersmale infertilityoligospermiaopiate addictionoxidative stresssemen analysissperm qualityspermatozoon motilitytesticular volumetestosterone blood levelthyrotropin blood level|
|MeSH:||Acrosome ReactionAdultAnalgesics, OpioidCase-Control StudiesChromatinDiagnostic and Statistical Manual of Mental DisordersDNA DamageGonadal Steroid HormonesGonadotropins, PituitaryHallucinogensHumansInfertility, MaleMaleMiddle AgedOpioid-Related DisordersOxidoreductasesSemenSpermatozoaSubstance Abuse DetectionYoung Adult|
catalase, 9001-05-2; follitropin, 9002-68-0; liothyronine, 6138-47-2, 6893-02-3; luteinizing hormone, 39341-83-8, 9002-67-9; opiate, 53663-61-9, 8002-76-4, 8008-60-4; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; testosterone, 58-22-0; thyrotropin, 9002-71-5;
Analgesics, Opioid; Chromatin; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Hallucinogens; Oxidoreductases, 1.-
Safarinejad, M.R.; P.O. Box 19395-1849, Iran; email:[email protected]
© Copyright 2013 Elsevier B.V., All rights reserved. © MEDLINE® is the source for the MeSH terms of this document.