Aim: Cardiac rehabilitation is a key part in the treatment of coronary artery disease (CAD) by its anti-inflammatory effects. However, the effect of exercise training programs on salivary concentrations of high-sensitivity C-reactive protein (hs-CRP) in patients with coronary artery disease has not been well studied. The objective of this study was to evaluate the effect of phase III cardiac rehabilitation on serum and salivary levels of hs-CRP, in relation to the anthropometric measurements of obesity and the relationship between salivary and serum levels of hs-CRP in CAD male patients. Materials and methods: Forty male volunteers (45-75 years) with CAD participated in 6 to 8 weeks of moderate intensity aerobic exercise training consisting of 45 minutes sessions of treadmill, stationary bicycle and arm ergometer. Anthropometric measurements of obesity, serum level of hs-CRP, stimulated and nonstimulated salivary level of hs-CRP were measured at the beginning, in the middle and at the end of exercise sessions. Results: All anthropometric measurements increased (p < 0.05) following cardiac rehabilitation except waist-hip ratio. Serum hs- CRP level reduced by 36% independent to the anthropometric measurements changes. Stimulated and nonstimulated salivary hs-CRP level decreased 68 and 54%, respectively, after 24 sessions of cardiac rehabilitation. Nonstimulated salivary hs-CRP levels correlated to serum levels of hs-CRP at baseline and after 24 sessions (p < 0.05). Conclusion: Phase III cardiac rehabilitation seems to be effective to improve serum and salivary hs-CRP concentrations independent of anthropometric measurements. Clinical significance: Nonstimulated salivary hs-CRP measurement could be a surrogate for blood measurement of hs-CRP during cardiac rehabilitation in male patients with CAD.
|EMTREE drug terms:||C reactive protein|
|EMTREE medical terms:||agedanthropometrybloodbody heightbody massbody weightchemistryclassificationcoronary artery diseasecyclingergometryheart ratehumankinesiotherapymalemetabolic equivalentmiddle agedobesityphysiologyproceduressalivawaist circumferencewaist hip ratiowaist to height ratiowalking|
|MeSH:||AgedAnthropometryBicyclingBody HeightBody Mass IndexBody WeightC-Reactive ProteinCoronary Artery DiseaseErgometryExercise TherapyHeart RateHumansMaleMetabolic EquivalentMiddle AgedObesitySalivaWaist CircumferenceWaist-Height RatioWaist-Hip RatioWalking|
C reactive protein, 9007-41-4;
Moghadam, B.A.; Department of Physical Therapy, Tehran University of Medical Sciences, Iran; email:[email protected]
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