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Opium Consumption Is Negatively Associated With Serum Prostate-Specific Antigen (PSA), Free PSA, and Percentage of Free PSA Levels

Safarinejad, Mohammad Reza and Asgari, Seyyed Alaeddin and Farshi, Alireza and Iravani, Shahrokh and Khoshdel, Alireza and Shekarchi, Babak (2013) Opium Consumption Is Negatively Associated With Serum Prostate-Specific Antigen (PSA), Free PSA, and Percentage of Free PSA Levels. Journal of Addiction Medicine, 7 (1). pp. 58-65. ISSN 1932-0620

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Addiction to opium continues to be a major worldwide medical and social problem. The study addressing the association between opium consumption and serum prostate-specific antigen (PSA) level is lacking. We determined the effects of opium consumption on serum PSA levels in opium-addict men. Our study subjects comprised 438 opiumaddict men with a mean age of 52.2 +/- 6.4 years (group 1). We compared these men with 446 men who did not indicate current or past opium use (group 2). Serum total PSA (tPSA), free PSA (fPSA), % fPSA, and sex hormones were compared between the 2 groups. The mean serum tPSA level was significantly lower in group 1 (1.05 ng/mL) than in controls (1.45 ng/mL) (P = 0.001). Opium consumption was also associated with lower fPSA (P = 0.001) and % fPSA (P = 0.001). Serum free testosterone level in opium-addict patients (132.5 +/- 42 pg/mL) was significantly lower than that in controls (156.2 +/- 43 pg/mL) (P = 0.03). However, no significant correlation existed between tPSA and free testosterone levels (r = 0.28, 95% CI, -0.036 to 0.51, P = 0.34). Among the patients with cancer in group 1, 35% were found to have high-grade tumor (Gleason score >= 7) compared with 26.7% in group 2 (P = 0.02). Total PSA and fPSA were strongly correlated with duration of opium use (r = -0.06, 95% CI, -0.04 to -0.08, P = 0.0001; and r = -0.05, 95% CI, -0.03 to -0.07, P = 0.0001, respectively). Opium consumption is independently and negatively associated with serum tPSA, fPSA, and % fPSA levels.

Item Type: Article
Subjects: WA Public Health
WX Hospital and other health Facilities
Divisions: Faculty of Law, Arts and Social Sciences > School of Education
Depositing User: ePrint Admin Admin
Date Deposited: 02 Jul 2013 05:58
Last Modified: 02 Jul 2013 05:58

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