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Efficacy of topical cromolyn sodium 4% on pruritus in uremic nephrogenic patients: A randomized double-blind study in 60 patients

Feily, Amir and Dormanesh, Banafshe and Ghorbani, Ali Reza and Moosavi, Zahra and Kouchak, Maryam and Cheraghian, Bahman and Mousavi, Seyed Seifollah Beladi and Mehrabian, Abolfath and Ranjbari, Nastaran (2012) Efficacy of topical cromolyn sodium 4% on pruritus in uremic nephrogenic patients: A randomized double-blind study in 60 patients. Int. Journal of Clinical Pharmacology and Therapeutics. ISSN 0946-1965

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Abstract

Abstract: Background: Chronic kidney disease (CKD)-associated pruritus is a significant clinical symptom affecting more than 50% of patients on hemodialysis. The availability of effective therapeutic options for management of CKD-associated pruritus remains a treatment challenge. Objective: The aim of this study was to compare cromolyn sodium cream 4% with placebo for the treatment of renal pruritus. Methods: A randomized, double-blind, prospective, 4-week study was designed. 60 patients with ESRD in our dialysis ward were randomly allocated to cromolyn sodium cream 4% or placebo. All of them completed the study period and their pruritus levels were evaluated 5 times (before the start of the study and at the end of each week for 4 weeks) using a Visual Analogue Scale (VAS). Results: The average pruritus score before administration of the drug in cromolyn sodium 4% and placebo group had been 2.5 +/- 1.1 and 2.7 +/- 1.3, respectively. In the cromolyn sodium 4% group the average score of pruritus gradually reduced to 0.3 +/- 1.3 and in the placebo group it gradually decreased to 1.3 +/- 1.4 at the end of Week 4. Method of t-test repeat analytical measurement indicated that there is no significant difference between reduction of pruritus in cromolyn 4% and placebo groups in the first and second week of the study, but in third and fourth week there were significant differences in reducing pruritus in favor of cromolyn sodium 4% (p < 0.04). Conclusion: According to our study cromolyn sodium cream 4% was more effective than placebo in reducing pruritus in uremic patients. We suggest to our colleagues to consider this treatment when facing a patient suffering from this symptom.

Item Type: Article
Subjects: W Health professions
WX Hospital and other health Facilities
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: ePrint Admin Admin
Date Deposited: 02 Jul 2013 06:43
Last Modified: 23 Jul 2013 08:38
URI: http://eprints.ajaums.ac.ir/id/eprint/61

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