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Immunomodulatory effects ofAloe veraand its fractions on response of macrophages againstCandida albicans

Farahnejad, Zohreh and Ghazanfari, Tooba and Yaraee, Roya (2011) Immunomodulatory effects ofAloe veraand its fractions on response of macrophages againstCandida albicans. Immunopharmacology and Immunotoxicology, 33 (4). pp. 676-681. ISSN 0892-3973

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Abstract: Natural products are important resources in traditional medicine and have been long used for prevention and treatment of many diseases. Medicinal plants have immunomodulatory properties. Aloe is one of the herbal medicines widely used in natural treatment and alternative therapy for various types of diseases. Aloe vera has been shown to modulate the immune response. Macrophages have been shown to play an essential role as the first line of defense against invading pathogen. Candida albicans is a communal and opportunistic pathogen in humans. In this study, we investigated the effect of A. vera extract and its fractions on infected macrophages with C. albicans. Viability of intraperitoneal macrophages was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test. Cell viability of infected macrophages was increased by the extract and dose of some isolated fractions dependently. The extract as well as R100, R50, R30, and R10 fractions of A. vera significantly increased cell viability of macrophages in most doses. R5 and F5 fractions showed no significant difference in comparison with control group. Further studies in animal models and human are necessary to clarify the modulatory effects of A. vera on macrophage function. Isolation and purification of A. vera components are also needed to find out the effective molecules.

Item Type: Article
Subjects: WA Public Health
WA Public Health > Public Health Education WA.18
WZ History of Medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: ePrint Admin Admin
Date Deposited: 02 Jul 2013 07:47
Last Modified: 02 Jul 2013 07:47

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